相关实验视频

Updated: Jul 15, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

对新辅助化疗反应的预测因素:三阴性乳腺癌的炎症和免疫标志物

Hiroki Kusama¹, Nobuyoshi Kittaka², Ai Soma¹

¹Department of Breast and Endocrine Surgery, Osaka International Cancer Institute, 3-1-69 Otemae Chuo-Ku, Osaka, 541-8567, Japan.

Breast cancer (Tokyo, Japan)

|October 2, 2023

概括

瘤透性淋巴细胞 (TIL),中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 预测三阴性乳腺癌 (TNBC) 中新辅助化疗 (NAC) 反应. 在预测治疗疗效方面,NLR可以作为TILs的替代标记.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
医学诊断医学诊断医学诊断

背景情况:

瘤透淋巴细胞 (TILs) 对于预测三阴性乳腺癌 (TNBC) 中的新辅助化疗 (NAC) 反应至关重要.
评估TIL水平仅限于专业设施.
中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR) 提供了可访问的,客观的替代品,这些替代品来自完整的血液计数.

研究的目的:

调查TILs,NLR和PLR对TNBC患者NAC疗效的预测价值.
确定NLR和PLR是否可以在这种情况下作为TILs的替代标记.

主要方法:

追溯分析66名TNBC患者,这些患者接受了基于人环素和税的NAC,随后进行了手术.
评估TILs,NLR和PLR作为病理完整反应 (pCR) 的预测指标.
利用接收机运行特征 (ROC) 曲线来确定TIL (20%),NLR (2.6) 和PLR (180) 的最佳切断值.

主要成果:

高TIL水平与较低的NLR (P=0.01) 和PLR (P=0.01) 相相关.
高TIL (OR4.28),低NLR (OR5.51) 和低PLR (OR3.29) 与pCR显著相关.
低NLR独立预测的pCR (OR6.59,P=0.01). 这是一个很好的方法.

结论:

TIL,NLR和PLR是TNBC中NAC疗效的有效预测指标.
TIL水平与NLR和PLR有显著的关联.
在预测PCR方面,NLR成为一个独立的预测因素和TIL的潜在替代品.

关键词:

乳腺新生体的形成.这是一种炎症标志物.病理学的完整反应.预测因素是一个预测因素.

更多相关视频

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.