肺癌患者的免疫相关不良事件
Guilherme Sacchi de Camargo Correia1, Tanmayi Pai1, Shenduo Li1
1Division of Hematology and Medical Oncology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA.
Current oncology reports
|October 2, 2023
概括
免疫检查点抑制剂 (ICI) 对肺癌治疗至关重要,但可能导致与免疫相关的不良事件 (irAEs). 本综述详细介绍了肺癌患者的irAE频率,管理以及对治疗反应的影响.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床试验 临床试验
背景情况:
- 自2015年以来,免疫检查点抑制剂 (ICI) 已经彻底改变了肺癌治疗.
- 与免疫相关的不良事件 (irAEs) 是与ICI治疗相关的重大临床挑战.
研究的目的:
- 审查FDA批准的肺癌ICI临床试验 (2015-2023年).
- 为了确定常见的irAEs的频率,包括甲状腺功能低下症,肺炎,腹/结肠炎,皮疹和肝炎.
主要方法:
- 临床试验和社会指导方针的综合文献综述.
- 分析的重点是病理生理学,流行病学,诊断,分级和irAEs的管理.
- 探索iRAE与治疗反应之间的关系.
主要成果:
- 肺癌的ICI治疗与一系列的irAEs有关.
- 常见的irAEs包括内分泌,肺,胃肠道,皮肤和肝脏的毒性.
- 有效的管理策略对于患者的护理和治疗的延续至关重要.
结论:
- 了解和管理irAEs对于优化肺癌ICI治疗至关重要.
- 本综述为在不同临床环境中管理IRE的瘤学提供者提供了指导.
- 由于它们可能导致严重和危及生命的结果,管理IREs至关重要.
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