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Updated: Jul 15, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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通过β-到-α形态转换器对TDP-43自我结合的氧化调节

Jinge Gu1, Xiaoming Zhou1, Lillian Sutherland1

  • 1Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235.

Proceedings of the National Academy of Sciences of the United States of America
|October 2, 2023
PubMed
概括

氧化触发了TDP-43蛋白的结构切换,将其从自我关联的β-链转移到α-螺旋. 这种受脂质影响的氧化开关可能控制细胞中的蛋白质定位和功能.

关键词:
在TDP-43的自我关联中.骨干气结合的气结合从β转为α的开关六二醇是一种氧化调节是一种氧化调节.

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