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Updated: Jul 15, 2025

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
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伊拉非布拉诺通过PPARβ/δ上调节EMT诱导体S100A4通过PPARβ/δ上调节

Meijian Zhang1, Emma Barroso1, Maria Ruart1

  • 1Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, Madrid, Spain; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|October 2, 2023
PubMed
概括

在一种与代谢功能障碍相关的脂肪肝炎 (MASH) 鼠标模型中,Elafibranor治疗改善了肝脏健康. 意想不到的是,它还增加了S100A4蛋白,通过PPARβ/δ激活促进了上皮质-介质酶过渡 (EMT).

关键词:
在ASB2中,它是ASB2.在EMT中,EMT是EMT.这是Elafibranor.马斯尔德 马斯尔德是什么意思这种PPARβ/δ类药物.在 S100A4 中使用.

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