在日本全国前性队列研究中对长期COVID的全面分析
Hideki Terai1, Makoto Ishii2, Ryo Takemura3
1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Keio Cancer Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Respiratory investigation
|October 2, 2023
概括
长期COVID症状最初影响几乎所有住院患者,随着时间的推移而减少,但影响生活质量. 在日本,女性性别和严重疾病是发展长期COVID的风险因素.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 由于SARS-CoV-2的快速传播,导致长期COVID的报道增加.
- 在日本人口中长期COVID的流行病学数据有限.
- 这项研究解决了这一差距,因为它是第一个全国性的日本长期COVID的前性队列研究.
研究的目的:
- 在日本患者中调查长期COVID的分布和特征.
- 为了确定与长期COVID发展相关的风险因素.
- 为日本人口提供关键的流行病学数据.
主要方法:
- 一项多中心的前性队列研究,涉及26个日本机构的1200名住院COVID-19患者 (≥18岁).
- 数据收集包括临床信息和通过医疗记录,问卷和智能手机应用程序报告的患者结果.
- 分析重点是1066例病例,包括医疗记录和患者报告结果的完整数据.
主要成果:
- 至少有一种长期COVID症状的患者比例从住院期间的93.9%下降到12个月后的33.0%.
- 长期COVID患者报告生活质量降低,抑郁,焦虑和恐惧水平更高.
- 长期COVID的危险因素包括女性性别,中年 (41-64岁),氧气需求和住院期间的危急疾病.
结论:
- 这项研究提供了日本长期COVID的第一个全国性流行病学数据.
- 在日本人群中阐明了关键的风险因素和症状患病率.
- 这些发现为日本未来的长期COVID研究和临床管理提供了必要的参考数据.
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