神经性病的遗传和神经基础是神经性病的一般因素
Yuri Kim1, Gretchen R B Saunders1, Alexandros Giannelis1
1Department of Psychology, University of Minnesota Twin Cities, 75 East River Road, Minneapolis, MN 55455, USA.
Biological psychology
|October 2, 2023
概括
这项全基因组关联研究发现了与神经病症相关的遗传变异. 这些变异集中在大脑表达的基因中,这表明这种人格特征的生物基础.
科学领域:
- 行为遗传学 行为遗传学
- 心理测量 心理测量 心理测量
- 神经科学是一个神经科学.
背景情况:
- 心理测量常见因素被辩论:它们是总结还是生物实体?
- 神经症是一种关键的人格特质,与各种心理健康状况有关.
研究的目的:
- 通过全基因组关联研究 (GWAS) 调查神经病的一般因素的遗传基础.
- 探索与神经病症相关的变体的生物基础和基因表达模式.
主要方法:
- 结构方程建模应用于来自约38万英国生物库参与者的GWAS数据.
- 根据它们的关联途径对显著遗传变异进行分类.
- 对基因表达和丰富的生物信息分析.
主要成果:
- 与神经病症相关的显著遗传变异在整个问卷项目中显示出一致的效应.
- 与神经性总因子相关的变异在大脑表达的基因附近或内被丰富.
- 丰富的基因组涉及大脑发育,突触功能和与焦虑相关的行为.
结论:
- 结果支持将心理测量常见因素解释为具有部分生物学基础.
- 与神经病症相关的遗传变异在大脑中不成比例地表达.
- 需要进一步的研究来了解共同因素和其他机制在人格结构的相互作用.
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