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Updated: Jul 15, 2025

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

对右心室功能障碍的多种和多种类分析.

Jenna B Mendelson¹, Jacob D Sternbach², Michelle J Doyle²

¹Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

|October 2, 2023

概括

由于未定义的目标,右心室衰竭 (RVF) 治疗方法缺乏. 与老鼠不同,猪在脂肪酸氧化和电子运输链蛋白中表现出分子变化,这些变化反映了人类的RVF反应.

关键词:

这就是为什么RV是RV.心脏磁力共振成像 (MRI)这是一项比较性研究.蛋白质组学蛋白质组学翻译学翻译学翻译学翻译学

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相关实验视频

Last Updated: Jul 15, 2025

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

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Published on: October 28, 2020

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科学领域:

心血管生物学心血管生物学
分子医学是分子医学.
比较病理学比较病理学

背景情况:

右心室衰竭 (RVF) 是心血管疾病中死亡的重要原因,但由于治疗目标定义不佳,缺乏有效的治疗方法.
目前对RVF的分子研究主要使用小动物模型,大动物模型和跨物种比较的数据有限.
了解物种间RVF的分子差异对于开发有效的人类疗法至关重要.

研究的目的:

为了在不同物种中比较右心室衰竭 (RVF) 的分子媒介.
为了评估一个大型动物模型 (猪) 在回顾人类RVF分子签名中的实用性.
通过比较转录组和蛋白组数据来确定RVF的潜在治疗点.

主要方法:

对照和肺动脉带带 (PAB) 猪进行了转录和蛋白质组分析,以评估RV缩,扩张和功能障碍.
分析了公开可用的转录基因/蛋白质基因数据,这些数据来自于RVF的老鼠模型和肺动脉高血压患者.
对猪,老鼠和人类的分子反应进行了比较,以确定保存和分歧的途径.

主要成果:

猪的肺动脉带带诱导显著的RV缩,扩张和功能障碍,由心脏MRI证实.
转录基因和蛋白质基因分析揭示了大鼠和猪之间脂肪酸氧化 (FAO) 和电子传输链 (ETC) 蛋白质调节的独特模式.
虽然老鼠表现出粮农组织和ETC的下调,但猪表现出上调,与人类RVF分子概况更接近. 这两种物种都显示了扩张性心肌病和心律失常性右心室心肌病途径的失调.

结论:

猪中RVF的代谢分子概况与动物相比,更类似于人类的RVF.
这些发现表明,RVF背后的分子机制存在物种特异性差异.
猪代表了一个更相关的大型动物模型来研究人类RVF的代谢方面,可能有助于确定治疗点.