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减肥会影响炎症性类风湿性疾病的疾病活性和治疗反应

Anne Tournadre¹, Marine Beauger²

¹Service de rhumatologie, hôpital G-Montpied, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France; Unité de nutrition humaine, UMR1019 INRA, université Clermont-Auvergne, 63000 Clermont-Ferrand, France.

Joint bone spine

|October 2, 2023

概括

肥胖会恶化慢性炎症性疾病,如类风湿性关节炎和牛皮,影响治疗的有效性. 通过饮食或手术减肥可以改善疾病活动和治疗反应,突出显示肥胖管理.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
代谢疾病代谢疾病

背景情况:

肥胖会改变脂肪组织,导致炎症 (促炎细胞因子,M1巨细胞,T淋巴细胞) 和减少扩张能力.
这种低级炎症加剧慢性炎症性疾病,降低治疗效率,并导致并发症.
肥胖与类风湿性关节炎 (RA),牛皮和牛皮性关节炎的发病率和严重程度增加有关,其影响取决于剂量.

研究的目的:

审查肥胖对慢性炎症性风湿性疾病的影响.
评估减肥干预措施对疾病活性和治疗反应的疗效.
突出肥胖查和管理在风湿病学中的重要性.

主要方法:

文献综述和现有关于肥胖,炎症和类风湿性疾病的研究的综合.
对减肥手术和低热量饮食干预措施的数据分析.
对治疗反应的检查,特别是与TNF抑制剂的治疗,与体重状况相关.

主要成果:

肥胖增加了RA,牛皮和牛皮性关节炎的发病率,并预测治疗反应较差,特别是对TNF抑制剂.
通过减肥手术减肥可以降低牛皮/牛皮关节炎的风险,并改善RA活动.
即使减轻5%的体重也会改善牛皮关节炎中TNF抑制剂的反应;减轻更多的体重也会产生更好的结果.

结论:

对于患有慢性炎症性风湿性疾病的患者来说,肥胖管理至关重要.
减肥干预措施可以明显改善疾病活动和治疗结果.
建议与肥胖管理一起改变生活方式,包括饮食,运动和戒烟.

关键词:

脂肪组织的脂肪组织.腹腔外科手术是什么意思体重指数 (Body Mass Index) 是一个指数.疾病活动疾病活动肥胖问题肥胖问题牛皮是一种病.牛皮关节炎牛皮关节炎类风湿性关节炎类风湿性关节炎类风湿性关节炎对治疗的反应反应.减肥的方法减肥的方法减肥的方法

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