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血中甲基-3与慢性艾滋病病毒患者的淋巴膜过率下降有关
Diana L Vares-Lum1, Louie Mar A Gangcuangco1,2, Juwon Park1,3
1Hawaii Center for AIDS, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
HIV research & clinical practice
|October 2, 2023
概括
携带艾滋病毒的人 (PLWH) 具有更高的加勒-3 (Gal-3) 水平,这是纤维化的一个标志物. 更高的Gal-3,而不是HIV状况,在这个队列中独立预测了功能下降 (eGFR).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 艾滋病毒感染者 (PLWH) 患慢性病 (CKD) 的比例较高.
- 艾滋病毒中CKD的发病因子是多因素的,包括并发病,抗逆转录病毒疗法,免疫问题和直接的病毒影响.
- 纤维化标志物加勒-3 (Gal-3) 在PLWH中对其与功能相关性进行了评估.
研究的目的:
- 调查与艾滋病毒感染者 (PLWH) 血中加勒-3 (Gal-3) 水平和功能之间的关联.
- 确定Gal-3是否是PLWH中估计膜过率 (eGFR) 降低的独立预测因子.
主要方法:
- 使用CKD-EPI标准评估估计的淋巴膜过率 (eGFR).
- 通过ELISA从储存的标本中测量了血甲基-3 (Gal-3) .
- 采用渐进式多重线性回归来分析与eGFR相关的因素.
主要成果:
- 与未感染艾滋病毒的个人相比,PLWH的Gal-3水平显著更高 (p=0.020).
- 在PLWH中观察到较低eGFR的趋势 (p=0.071).
- 多变量分析显示,Gal-3独立预测降低了eGFR (p<0.001),而HIV状况没有.
结论:
- 与未感染艾滋病毒的人相比,与艾滋病毒感染者 (PLWH) 相比, Galectin-3 (Gal-3) 在感染艾滋病毒的人群中升高.
- 在调整后的分析中,Gal-3,而不是HIV状态,与降低功能 (eGFR) 有显著的关联.
- 需要进一步的研究来澄清Gal-3作为PLWH中功能生物标志物的作用.
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