支气管肺功能障碍症 - 相关的肺高血压:一个更新的审查
Ahmed El-Saie1, Nidhy P Varghese2, Melissa K Webb3
1Section of Neonatology, Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO, USA.
Seminars in perinatology
|October 2, 2023
概括
伴有肺高血压 (PH) 的支气管肺功能障碍 (BPD) 是早产的一个严重并发症. 本综述总结了最近在预防和管理BPD-PH方面的进展,以改善婴儿的结果.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 心脏病学 心脏病学
背景情况:
- 支气管肺功能障碍 (BPD) 是早产婴儿的主要慢性肺部疾病,由于新生儿存活率提高,其发病率越来越高.
- 肺高血压 (PH) 是 BPD 的严重并发症,影响近三分之一的婴儿中等到严重的BPD.
- 目前用于BPD-PH的治疗方法显示出低于最佳的反应,突出显示出需要新的管理策略.
研究的目的:
- 提供关于肺高血压 (BPD-PH) 伴随支气管肺功能障碍的最新进展的全面审查.
- 巩固目前关于BPD-PH的发病,病理生理学,诊断,治疗和结果的知识.
- 为开发新策略提供信息,以预防和管理早产婴儿的这种关键状况.
主要方法:
- 对BPD-PH.最近的研究进行系统的文献综述.
- 现有证据的多学科团队分析.
- 综合有关病原,诊断和治疗干预的数据.
主要成果:
- 新生儿护理的进步增加了生存率,但保持了高的BPD发病率.
- BPD-PH显著增加了早产婴儿的发病率和死亡率.
- 肺血管扩张剂通常是无效的,需要探索新的治疗途径.
结论:
- 对BPD-PH的发病,诊断和治疗的全面了解至关重要.
- 开发新的治疗策略对于改善患有BPD-PH的婴儿的治疗结果至关重要.
- 跨学科的合作是推动照顾早产婴儿BPD-PH的关键.
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