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动脉样硬化的诊断方式在宏循环中的性别差异
Peter L M Kerkhof1, Francesco Tona2
1Dept. Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Location VUmc, Amsterdam, the Netherlands.
Atherosclerosis
|October 2, 2023
概括
动脉样硬化,是心血管疾病的前体,发展得很早,并因性别而异. 本综述详细介绍了诊断工具,生物标志物和机器学习,以评估其进展和临床影响.
科学领域:
- 心血管医学 心血管医学
- 医疗成像医学成像
- 生物标志物 生物标志物
背景情况:
- 无症状动脉样硬化在生命早期就开始了.
- 它是导致心血管疾病和死亡的主要原因.
- 进展可以表现出性别特定的模式.
研究的目的:
- 审查目前对宏循环动脉样硬化的诊断工具.
- 突出与年龄相关的和性别特异性的特征.
- 识别知识缺口和未来的研究方向.
主要方法:
- 讨论了先进的成像技术 (CT,PET,IVUS,MRI,OCT).
- 对衍生分数系统的审查 (阿加斯顿,根西尼,利曼,语法).
- 评估血液动力学指数,斑块特性,狭窄度 (FFR),生物标志物 (MMP,VEGF,miRNA) 和机器学习应用.
主要成果:
- 对动脉样硬化的诊断方式的全面概述.
- 强调性别差异和与年龄相关的变化.
- 确定局限性和未来调查的领域.
结论:
- 早期检测和表征动脉样硬化是至关重要的.
- 多模式诊断方法,包括成像,生物标志物和人工智能,是必不可少的.
- 需要进一步的研究来解决性别特异性方面和临床影响.
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