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干扰素通过ISG15恢复BRCA缺陷细胞中的复制叉稳定性和细胞活力

Ramona N Moro1, Uddipta Biswas1, Suhas S Kharat2

  • 1University of Zurich, Institute of Molecular Cancer Research, 8057, Zurich, Switzerland.

Nature communications
|October 2, 2023
PubMed
概括

干扰素刺激的15基因 (ISG15) 和它的结合 (ISGylation) 保护新生的DNA免受降解. 干扰素β (IFNβ) 治疗增强了BRCA1/2-缺陷细胞中的DNA复制叉稳定性,通过ISG15.

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