补充HCG并没有加速tunica albuginea重塑以促进阴茎生长
Tao Li1,2, Yuan Tian2, Quliang Zhong2
1Department of Urology, Guizhou Provincial People's Hospital, 184 Zhongshan East Road, Guiyang, 550002, Guizhou, People's Republic of China.
Scientific reports
|October 2, 2023
概括
这项研究发现,虽然抗lysyl氧化酶 (Anti-LOX) 加上真空勃起装置 (VED) 有效地延长阴茎,但补充人类胆性腺激素 (HCG) 并不能增强这种效果. 观察到阴茎生长,但HCG与Anti-LOX + VED治疗没有协同作用.
科学领域:
- 安德罗学与人类学
- 再生医学是一种再生医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 阴茎长短会导致性功能障碍和心理困扰.
- 雄激素对阴茎发育至关重要;丸激素替代剂用于微型阴茎.
- 以前的研究表明,抗lysyl氧化酶 (Anti-LOX) 和真空勃起装置 (VED) 改造tunica albuginea以延长阴茎.
研究的目的:
- 调查人类胆性淋巴激素 (HCG) 补充是否可以加速由Anti-LOX + VED诱导的tunica albuginea重塑.
- 为了确定HCG在与Anti-LOX和VED治疗相结合时对阴茎生长的影响.
主要方法:
- 42只雄性大鼠被分为七个组,包括对照组,抗LOX,HCG,VED,抗LOX+VED,HCG+VED和抗LOX+HCG+VED.
- 干预持续了四周,随后测量了阴茎长度,暴露的阴茎长度和勃起功能.
- 分析了血清激素水平和阴茎体洞穴组织学.
主要成果:
- 与对照组相比,所有干预组都显示阴茎长度显著增加.
- 反LOX + VED增加了阴茎长度26%,暴露长度19%.
- 单独使用HCG显示阴茎长度略有增加 (8%),但对暴露长度的影响很小 (3%);它与Anti-LOX + VED没有协同作用,组合组显示的结果与单独使用Anti-LOX + VED相似.
- HCG增加了丸激素,二丸激素和雄激素受体 (AR) 的表达.
- 没有一个小组经历了正常勃起功能的改善或恶化.
结论:
- 抗LOX + VED通过tunica albuginea重塑有效地延长阴茎.
- 补充HCG刺激雄激素的产生和AR表达,但在与Anti-LOX + VED结合时不会增强阴茎的延长.
- Anti-LOX + VED的组合对阴茎延长是有效的,但HCG没有提供协同效益.
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