一个基于坐标的对人类杏仁体连接性改变的元分析,与早期生活中的逆境有关
Eline J Kraaijenvanger1, Tobias Banaschewski1, Simon B Eickhoff2,3
1Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, Germany.
Scientific reports
|October 2, 2023
概括
生命早期的逆境 (ELA) 改变了杏仁体与前带皮质 (ACC) 和海马的连接. 这些神经生物学变化可能会增加对未来精神病理的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 早期的生活逆境 (ELA) 可以影响神经生物学发展,可能导致心理病理的潜在脆弱性.
- 了解这些漏洞背后的神经机制对于早期干预至关重要.
研究的目的:
- 通过基于坐标的元分析,识别与ELA相关的杏仁体功能连接的融合变化.
- 调查这些变化如何在不同的fMRI范式,半球,年龄组和逆境类型中变化.
主要方法:
- 在五个电子数据库中系统搜索ELA的休息状态和基于任务的fMRI研究.
- 49项符合条件的研究 (n=3162名参与者) 的基于协调的元分析.
- 基于半球,范式,年龄和逆境评估方法的子分析.
主要成果:
- 在杏仁体与前带皮质 (ACC) 和左海马体的功能连接中发现了显著的融合变化.
- 在右桃体中播种的连接受到影响,与ACC的连接性降低.
- 在休息状态 (桃体-ACC) 和基于任务的范式 (桃体-海马体) 中观察到变化,特别是在成年人中.
结论:
- ELA与杏仁体功能连接的广泛变化有关,特别是与ACC和海马.
- 这些神经生物学变化可能代表一种潜伏的脆弱性机制,用于在以后的生活中发展心理病理.
- 研究结果强调了早期经验对大脑发育和心理健康的持久影响.
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