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评估体质指数和25-基维生素D水平对基底细胞癌的影响,使用孟德尔随机化

Xuezhao Chen^1,2, Shan Song^1,3, Jinyu Shi^1,4

¹Shanxi Medical University, Taiyuan, China.

Scientific reports

|October 2, 2023

概括

较高的体重指数 (BMI) 与基底细胞癌 (BCC) 的风险降低有关,作为保护因素. 血清维生素D水平似乎没有对BCC风险产生因果影响.

科学领域:

皮肤病学皮肤病学
遗传学是一个遗传学.
流行病学流行病学

背景情况:

基底细胞癌 (BCC) 的发病率在肤浅的人群中正在上升.
肥胖和维生素D水平被怀疑是BCC发展的因素.
遗传倾向需要进一步调查.

研究的目的:

为了研究体质指数 (BMI),血清25-基维生素D (25(OH) D) 水平和基底细胞癌 (BCC) 风险之间的因果关系.
使用门德尔的随机化 (MR) 来评估这些关联.
为BCC预防策略提供基于证据的见解.

主要方法:

使用两个样本的门德尔随机化 (MR) 分析.
从大型全基因组关联研究 (GWAS) 中利用的单核酸多态 (SNPs) 与BMI (n=443) 和25(OH) D水平 (n=96) 相关.
进行单变量和多变量MR分析,并进行结果验证的灵敏度分析.

主要成果:

较高的BMI显示与BCC风险存在显著的反向因果关系 (OR=0.90,P=0.02).
这种BMI对BCC的保护作用在调整25(OH) D水平 (OR=0.88,P=0.008) 后仍然存在.
血清25(OH) D水平没有被发现与BCC风险有因果关系 (OR=1.02,P=0.67).

结论:

体重指数升高是一个独立的防护因子,可以预防基底细胞癌 (BCC).
血清维生素D水平没有证明与BCC风险的因果关系.
补充维生素D不太可能是减少BCC发病率的有效策略.

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