代谢学和机器学习技术显示,发芽增强了有色米的多营养特性
Rhowell Jr N Tiozon1,2, Nese Sreenivasulu1, Saleh Alseekh2
1Consumer-driven Grain Quality and Nutrition Center, Strategic Innovation Platform, International Rice Research Institute, Los Baños, 4030, Philippines.
Communications biology
|October 2, 2023
概括
发芽的有色米芽 (PRS) 提高了营养物质的生物可用性,增加了诸如,微量营养素和黄等有益化合物. 这一过程与特定的基因激活相关,可以帮助培育米品种,以打击营养不良.
科学领域:
- 农业科学 农业科学
- 营养生物化学 营养生物化学
- 植物遗传学 植物遗传学
背景情况:
- 提高大米的营养价值对全球健康至关重要,特别是在依赖大米的国家面临营养不良.
- 发芽是一种有前途的生物处理技术,可以提高谷物中营养素的生物可用性.
- 关于发芽的有色米芽 (PRS) 的营养影响的数据有限.
研究的目的:
- 为了研究发芽对有色米芽 (PRS) 的营养特征的影响.
- 在发芽期间识别关键基因和与增强的营养化合物相关的遗传标记.
- 开发一个预测模型,用于PRS的多营养性质.
主要方法:
- 发芽与未发芽的有色素大米的比较分析.
- 代谢分析,以识别累积的化合物 (二,GABA,黄).
- 全基因组关联研究 (GWAS) 和亚型分析以确定相关基因 (CHS1,UGT).
- 随机森林建模,结合营养预测的遗传标记.
主要成果:
- 发芽显著增加了自由和基本微量营养素 (Ca,Na,Fe,Zn) 和维生素 ( рибофлавин,生物素) 的水平.
- 代谢分析证实了二,GABA和各种类黄的积累.
- GWAS确定了与黄类生物合成相关的特定基因 (例如,CHS1,UGT),具有显著的等位基因差异.
- 使用遗传标记物的预测模型实现了高准确度 (97.7%) 的多营养性质.
结论:
- 发芽有效地提高了有色米芽的营养质量.
- 特定的遗传通路和标记与有益化合物的增加有关.
- 这项研究为培育营养改善的米品种提供了基础,以应对全球卫生挑战.
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