聚合物纳米囊含有臭氧化油和特尔比纳芬化物作为潜在的治疗皮肤病菌
Francielli Lima Dos Santos1, Júlia Capp Zilles2, Andressa Urbano Machado1
1Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Azenha, Porto Alegre, RS, 90610-000, Brazil.
AAPS PharmSciTech
|October 2, 2023
概括
开发的Eudragit® RS100纳米囊含有特比纳芬化物和臭氧化向日种子油,显示出对皮肤细胞的抗真菌活性增强. 这种新型配方为皮肤感染提供了潜在的高效治疗方法,可能减少药物剂量和应用频率.
科学领域:
- 制药技术 制药技术 制药技术
- 菌类学 菌类学是指菌类学.
- 皮肤病学 皮肤病学
背景情况:
- 特尔比纳芬化抑制了烯氧化酶,破坏了真菌膜.
- 臭氧化油通过活性氧物种提供抗菌性质.
- 皮肤植物病需要有效的局部治疗.
研究的目的:
- 开发和描述Eudragit® RS100纳米囊,其中封装了terbinafine化和臭氧化日向种子油.
- 评估这些纳米囊在体外对皮肤细胞的性能.
主要方法:
- 预制聚合物方法的界面沉积用于纳米囊制备.
- 特性包括粒子大小,泽塔潜力,pH值,药物含量和封装效率.
- 在实验室中进行了药物释放,皮肤透和抗真菌活性测试.
主要成果:
- 纳米囊的粒子大小为~150nm,泽塔电位为+6mV,pH值为2.2.
- 药物含量为~95%,封装效率为53%.
- 纳米囊表现出受控释放,皮肤透率降低,在体外抗真菌活性优于特尔比纳芬溶液.
结论:
- 欧德拉吉特RS100纳米囊有效地封装了特比纳芬化和臭氧化油.
- 开发的纳米载体系统显示了治疗皮肤植物病的巨大潜力.
- 需要进一步的体内研究来确认安全性和有效性.
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