高加速的自由呼吸实时心肌标记用于运动心血管磁共振
Manuel A Morales1, Siyeop Yoon1, Ahmed Fahmy1
1Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave., Boston, MA, 02215, USA.
概括
一种新的实时心磁共振标记技术可以准确量化运动期间心肌变形. 这种先进的方法显示了在临床环境中改善心脏评估的希望.
科学领域:
- 心血管成像 - 心血管成像
- 生物医学工程 生物医学工程
- 医学物理 医学物理
背景情况:
- 进行心血管磁共振 (Ex-CMR) 心肌标记对于量化心肌变形至关重要.
- 目前的心电图 (ECG) 分段序列对Ex-CMR应用有局限性.
研究的目的:
- 为3T Ex-CMR开发和评估一种高度加速的实时标记技术.
- 评估使用这种新技术量化心肌变形的可行性和准确性.
主要方法:
- 开发了一种12倍加速的平衡稳定状态自由前行实时标记技术,使用随机卡特西亚抽样,截断的外相编码和深度学习.
- 在休息和Ex-CMR研究中进行了测试,收集了ECG细分和实时标记图像.
- 量化心肌变形 (全球周长应变 - GCS) 和评估图像质量和文物水平.
主要成果:
- 在90%的休息情况下成功量化变形,96%的运动前,84%的运动后在Ex-CMR中.
- 在ECG细分和实时GCS测量之间存在良好的相关性 (r=0.71).
- 良好的至优秀的重复性 (ICC=0.86) 与低变化系数 (4.7%).
结论:
- 开发了一种高度加速的实时标记技术,证明了Ex-CMR心肌变形量化的潜力.
- 需要进一步的研究来确定该技术的临床效用.
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