1型干扰素刺激的基因表达和儿童类风湿性疾病中的疾病活性:不需要复合得分?
Christina Weiden1, Melanie Saers1, Tobias Schwarz2
1University Hospital Muenster, Muenster, Germany.
ACR open rheumatology
|October 3, 2023
概括
个人1型干扰素刺激基因 (ISG) 表达与儿科类风湿性疾病 (如青少年皮肤肌炎) 的疾病活性有很强的相关性. 这一发现简化了临床评估,并降低了与复合分数相比的成本.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 遗传学 是一个遗传学.
背景情况:
- 风湿性疾病涉及免疫系统过度活化.
- 1型干扰素 (IFN) 途径与这些情况有关.
- 评估疾病活动往往需要复杂的生物标志物.
研究的目的:
- 研究1型全血IFN刺激基因 (ISG),IL18和CXCL9表达与儿科类风湿性疾病中的临床疾病活性之间的相关性.
- 为了确定组合型1 IFN评分的最佳ISG数量.
主要方法:
- 收集了来自171名患有各种类风湿性疾病的儿科患者和38名对照者的RNA和临床数据.
- 使用实时PCR评估了6个ISG,IL18和CXCL9的表达.
- 对单个和复合基因表达数据进行了相关性和值分析.
主要成果:
- 在结合组织疾病 (CTD) 中,ISG表达与疾病活性有很强的相关性,特别是青少年皮肤肌炎 (JDM) 和干扰性皮肤病 (IFNP).
- 在全身性自身炎症性疾病 (SAID) 中,相关性很小.
- 单个ISG或小集显示与六个ISG复合分数相比较的相关性,简化了分析.
结论:
- 个体ISG表达力强烈地反映了CTD和IFNP的临床疾病活性,特别是JDM.
- 简化ISG分析对于临床常规来说具有成本效益.
- 不同的值水平表明1型IFN过度激活机制在疾病中的多样性.
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