COVID-19疗法与住院患者胃肠道出血之间的关联:一项多站点回顾性研究
Noah A Wiedel1, Harlan Sayles2, Jessica Larson3
1Department of Internal Medicine, Division of Hospital Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
胃肠道出血发生在住院COVID-19患者的0.44%. 德克萨松降低了出血风险,而雷梅西维尔单一治疗增加了成年人上部胃肠道出血风险.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 关于住院COVID-19患者胃肠道出血 (GIB) 发生率的数据有限.
- 影响GIB的因素,包括并发症,人口统计和治疗,需要进一步调查.
研究的目的:
- 确定COVID-19的住院成年人GIB的发病率.
- 分析患者人口统计,并发症,COVID-19疗法和药物对GIB发展的影响.
主要方法:
- 使用国家COVID队列协作数据库进行回顾性研究.
- 包括512,467名住院的美国成年人 (年龄大于18岁) 在COVID-19感染的14天内.
- 分析GIB发展及其相关风险因素.
主要成果:
- 在住院COVID-19患者中,GIB发生在0.44%的患者中.
- 与GIB相关的危险因素包括胃潰瘍疾病,肥胖,慢性病和吸烟障碍.
- 在女性,拉丁裔个人和接种疫苗的患者中观察到较低的GIB风险.
- 德克萨米他 (单独或与雷德西维尔) 与GIB风险降低有关;雷德西维尔单一治疗与上部GIB风险增加有关.
结论:
- 德克萨米他单独或与雷梅西维尔一起使用,与住院COVID-19患者的GIB风险较低有关.
- 雷梅西维尔单一治疗与上部GIB的风险增加有关.
- 质子抑制剂的使用在GIB患者中更高,可能是为了治疗而不是作为危险因素.
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