根据疾病亚型,刺激性肠综合征的饮食和肠道微生物相关性
Yiqing Wang1,2, Wenjie Ma1,2, Raaj Mehta1,2
1Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Gut microbes
|October 3, 2023
概括
饮食和肠道微生物影响着刺激性肠道综合征 (IBS) 亚型. 特定的饮食和微生物变化,包括*Faecalibacterium prausnitzii*变异,与腹 (IBS-D) 和便秘 (IBS-C) 的IBS有关.
科学领域:
- 胃肠病学和营养科学 胃肠病学和营养科学
- 微生物组研究 微生物组研究
- 饮食对肠道健康的影响
背景情况:
- 刺激性肠综合征 (IBS) 的病原发生涉及饮食和肠道微生物群之间的复杂相互作用,但仍然不完全理解.
- 了解这些相互作用对于开发针对不同IBS亚型的有针对性的干预措施至关重要.
研究的目的:
- 研究饮食因素与肠道微生物群组成在不同类型的刺激性肠综合征 (IBS) 中的相互作用.
- 为了确定IBS患者的饮食,微生物多样性和功能途径的亚型特定变化.
主要方法:
- 在ZOE PREDICT 1研究中分析了969名参与者 (18-65岁) 的食物频率问卷数据和便元基因组数据.
- 根据罗马III标准对IBS亚型 (腹占主导的IBS-D,便秘占主导的IBS-C) 的分类.
- 多变量调整的线性回归以确定饮食,微生物种类和IBS亚型之间的关联.
主要成果:
- IBS-D参与者消耗了更多健康的植物性食物和纤维; IBS-C参与者消耗了更多不健康的植物性食物.
- 与非IBS和IBS-C组相比,IBS-D组的微生物多样性较低.
- 具体的微生物变异包括IBS-C中的炎症促成类型 (例如,大肠杆菌) 的增加和IBS-D中的严格无气体 (例如,Faecalibacterium prausnitzii) 的丧失.
- 确定了饮食与微生物群的相互作用,纤维/铁摄入量和IBS-D之间存在更强的关联,这些关联在具有较高*Faecalibacterium prausnitzii*丰度的个体中更强.
结论:
- 结果表明亚型特定的饮食习惯,肠道微生物组成和IBS中的功能.
- 饮食与微生物群的相互作用,特别是涉及*Faecalibacterium prausnitzii*,在IBS的发病过程中起着重要作用.
- 结果为开发针对IBS管理的个性化,微生物组知情的饮食干预措施提供了洞察力.
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