药物诱导的肝损伤 - 2023年更新
Rebecca Allison1, Asha Guraka1, Isaac Thom Shawa1
1College of Science and Technology, University of Derby, Derby, UK.
概括
药物诱导性肝损伤 (DILI) 是药物引起的肝损伤,通常是特异性的. 本综述探讨了DILI机制,风险因素和流行病影响,强调了更好的预防和诊断的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 药物诱导性肝损伤 (DILI) 是药物暴露造成的肝损伤,分为肝细胞,胆固醇或混合,并且可能涉及免疫反应.
- DILI可以是内在的 (剂量依赖) 或特异性的 (自发的);本文重点介绍的是特异性的DILI.
- 已确定的分子机制包括线粒体功能障碍,氧化应激,亡/亡和免疫介导的胆管损伤,尽管根本原因尚不清楚.
研究的目的:
- 审查关于DILI机制的当前知识.
- 为了确定DILI的潜在风险因素.
- 检查COVID-19大流行对DILI演示和研究的影响.
主要方法:
- 分析了来自全球来源的回顾性队列研究.
- 关于已建立和潜在的DILI机制的文献综述.
- 检查流行病学模式和风险因素.
主要成果:
- 该综述综合了目前对DILI机制的理解,包括线粒体功能障碍和氧化应激.
- 讨论了潜在的风险因素和COVID-19大流行对DILI的影响.
- 由于治疗选择有限,强调了对DILI预防策略的关键需求.
结论:
- 对DILI机制,生物标志物和因果关系评估的进一步研究是必不可少的.
- 了解流行病学模式和风险因素对于预防至关重要.
- 随着COVID-19的流行,DILI面临新的挑战和新的研究途径.
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