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相关概念视频

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction01:16

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

10.3K
The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
10.3K
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry01:29

Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

4.6K
Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
4.6K
Crossed Aldol Reactions: Overview01:04

Crossed Aldol Reactions: Overview

5.4K
Crossed aldol addition is the reaction between two different carbonyl compounds under acidic or basic conditions. Here, both the carbonyl compounds function as nucleophiles and electrophiles. As shown in Figure 1, such a reaction yields a mixture of products, two of which are formed via self-condensation, while the remaining two are formed via crossed-condensation. Without adjustment, the reaction's usefulness in organic chemistry is decreased.
5.4K
Introduction to Electrophilic Addition Reactions of Alkenes02:24

Introduction to Electrophilic Addition Reactions of Alkenes

8.0K
The double bond in a simple, unconjugated alkene is a region of high electron density that can act as a weak base or a nucleophile. The filled π orbital (HOMO) of the double bond can interact with the empty LUMO of an electrophile. A bonding interaction occurs when the electrophile attacks between the two carbons; the electrophile then accepts a pair of electrons from the π bond and undergoes addition across the double bond, yielding a single product.
Addition and elimination...
8.0K
Halogenation of Alkenes02:46

Halogenation of Alkenes

15.8K
Halogenation is the addition of chlorine or bromine across the double bond in an alkene to yield a vicinal dihalide. The reaction occurs in the presence of inert and non-nucleophilic solvents, such as methylene chloride, chloroform, or carbon tetrachloride.
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
15.8K
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene01:14

Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene

2.5K
Electrophilic addition of halogens to alkenes proceeds via a cyclic halonium ion to form a 1,2-dihalide or a vicinal dihalide.
2.5K

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Updated: Jul 15, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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不同和选择性的轻基交叉合.

Zi-Chao Wang1, Jia-Wen Zhang1, Ming Joo Koh2

  • 1State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P. R. China.

Angewandte Chemie (International ed. in English)
|October 3, 2023
PubMed
概括

这项研究引入了一种新的催化碳基化轻的碳基化. 该方法有效地将丰富的烯酸转化为有价值的化学物质,如基烯和复杂烯.

关键词:
碳基化是碳基化的一种.交叉合 交叉合 交叉合轻的基基 轻的基基N-异环碳化合物 N-异环碳化合物催化剂 催化剂

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科学领域:

  • 有机化学 有机化学
  • 催化剂是一种催化剂.
  • 石油化学 石油化学

背景情况:

  • 轻烯酸是随时可用的石化原料.
  • 将烯酸转化为高价值化学物质是合成中的一个关键挑战.

研究的目的:

  • 开发一种区域选择性方法来提升轻烯的质量.
  • 通过催化,使的多种功能化.

主要方法:

  • 轻基的区域选择性碳基化.
  • 在现场用减少剂,基或格林纳德试剂捕获.
  • 在催化剂上使用重的N-异环碳联体.

主要成果:

  • 有效的1,2-功能化和二碳功能化基.
  • 分支选择性的赫克型交叉合反应.
  • 简化基烯和复杂烯的合成.

结论:

  • 建立了一个模块化和分散的烯升级平台.
  • 开发的催化策略在药物化学和工业中提供了广泛的应用.