脂质概况作为胸腔腹腔外科手术后器官功能障碍的预测标记:一个横截面研究
Sarvin Sanaie1, Sanam Dolati2, Majid Montazer3
1Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Iranian journal of medical sciences
|October 3, 2023
概括
手术后高总胆固醇 (TC) 水平会增加死亡率和器官功能障碍的风险. 相反,低密度脂蛋白胆固醇 (LDL-C),高密度脂蛋白胆固醇 (HDL-C) 和甘油三 (TG) 具有保护作用,改善患者的治疗结果.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 外科手术的结果
背景情况:
- 血总胆固醇 (TC) 是一种负的急性相反应剂.
- 血清胆固醇水平通常在诸如创伤,败血症,烧伤,肝功能障碍和手术后等病理状况下降.
- 调查脂质资料在预测术后器官功能障碍中的作用至关重要.
研究的目的:
- 探索胸腔腹腔外科手术后脂质样本和器官功能障碍之间的关联.
- 为了确定脂质标志物是否可以预测患者的结果,包括死亡率和停留时间.
主要方法:
- 在胸腔腹腔外科手术后进入ICU的患者的横截面研究.
- 测量血清总胆固醇 (TC),LDL-C,HDL-C,甘油三 (TG) 和白蛋白.
- 后勤回归分析用于评估脂质标记物与器官功能障碍,死亡率和临床结果之间的关系.
主要成果:
- 血清TC升高显著增加了死亡,,肝脏和呼吸系统功能障碍的风险.
- 较低的LDL-C,HDL-C和TG水平与不良结果有关.
- 脂质概况与停留时间,机械通风持续时间和血管压缩剂使用有关.
结论:
- 血清TC是术后死亡率和器官功能障碍的危险因素.
- LDL-C,HDL-C和TG显示出对不良结果的保护作用.
- 脂质资料是评估手术后患者预后的有价值指标.
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