伴有和没有艾伦综合征的阅读障碍:对能力和脑源性神经营养因子水平影响的研究
Ehab R Abdelraouf1,2, Ayman Kilany1,3, Mohamed E Elhadidy1
1Children with Special Needs Research Department, Medical Research and Clinical Studies Institute National Research Centre Cairo Egypt.
Ibrain
|October 3, 2023
概括
患有发育性阅读障碍 (DD) 和艾伦综合征 (IS) 的儿童表现出明显的认知缺陷和较低的脑衍生神经营养因子 (BDNF) 水平. 这些发现表明BDNF可能会影响DD的认知和视觉处理.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 是一个遗传学.
背景情况:
- 并发性艾伦综合征 (IS) 可能会影响发育性阅读障碍症 (DD) 的儿童的阅读和认知技能.
- 大脑衍生神经营养因子 (BDNF) 涉及到大脑的认知和视觉处理区域.
研究的目的:
- 评估 dyslexic 儿童的认知能力,有或没有IS.
- 为了比较IS的阅读障碍儿童,没有IS的阅读障碍儿童和神经类型 (NT) 儿童的血BDNF水平.
主要方法:
- 参与者包括60名DD儿童 (30名IS,30名没有) 和30名NT儿童.
- 用标准化测试 (爱伦阅读感知量表,斯坦福比内特,DAT,ITPA) 评估认知能力.
- 血BDNF水平通过酶相关免疫吸收试验 (ELISA) 进行测量.
主要成果:
- 与DD+IS组相比,DD+IS组表现出更多的视觉闭包和一分钟写作缺陷,但与DD组相比,语音细分缺陷较少.
- 患有DD的儿童 (有或没有IS) 的血BDNF水平明显低于NT儿童 (p < 0.001).
- 同时存在的IS影响了某些阅读和非阅读任务的性能.
结论:
- 患有DD的儿童中IS的存在与特定的认知和视觉处理差异有关.
- 降低的BDNF水平可能会导致DD儿童观察到的认知和阅读缺陷.
- 进一步研究BDNF在DD和IS中的作用是有必要的.
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