在患有椎脊髓炎骨髓病的患者中,异常的内在大脑功能网络动态
Guoshu Zhao1,2, Yaru Zhan1,2, Jing Zha3
1Department of Radiology, the First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, Jiangxi 330006 People's Republic of China.
Cognitive neurodynamics
|October 3, 2023
概括
椎脊髓炎 (CSM) 改变了大脑网络动态,显示在特定功能状态中花费的时间更长. 这表明CSM患者的大脑网络不稳定.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 网络科学 网络科学
背景情况:
- 椎脊髓炎 (CSM) 涉及脊髓压缩,可能影响大脑功能.
- 在CSM中大脑功能的重组,特别是关于动态功能网络的重组,尚不清楚.
研究的目的:
- 在CSM患者中研究动态功能连接 (dFC).
- 分析功能连接状态和网络拓变量的时间特征.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于88名CSM患者和77名健康对照 (HCs).
- 滑动时间窗口分析和K-means集群确定了dFC变化模式.
- 图形理论评估了全脑功能网络的拓组织.
主要成果:
- 在所有参与者中观察到四种动态功能连接状态.
- 与HCs相比,CSM患者在状态2中的平均停留时间明显长.
- 网络切换涉及关键的大脑网络,如ECN,SN,DMN和SMN.
- CSM患者在他们的动态网络中显示出可变的拓性质.
结论:
- 动态功能连接状态为CSM中的内在大脑活动提供了洞察力.
- 观察到的拓组织变异表明CSM患者中大脑网络的潜在不稳定性.
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