在听觉中脑的听觉中脑中,声音和动作的混合表示
G L Quass1, M M Rogalla1, A N Ford1
1Kresge Hearing Research Institute, Department of Otolaryngology - Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.
bioRxiv : the preprint server for biology
|October 3, 2023
概括
听觉中脑中的神经活动将声音线索与行为行为相结合. 这种听觉中脑人口代码反映了声音和动作,影响了感知和学习.
科学领域:
- 神经科学是一个神经科学.
- 审计处理 审计处理
- 感官整合 感官整合
背景情况:
- 将感官输入与行为结果联系起来,对大脑功能至关重要.
- 高层大脑区域的"混合表示"整合了感觉和行为变量,用于感知,学习和可塑性.
- 在上游大脑区域,如中脑,这种整合的程度仍然不太清楚.
研究的目的:
- 为了研究听觉中脑中的整合计算.
- 为了确定听觉中脑神经元是否代表感官线索和行为行为.
- 探讨下层结肠 (IC) 在感觉-动作集成中的作用.
主要方法:
- 细胞分辨率的2光子成像在下 (IC) 的表面外层.
- 在执行基于奖励的听觉心理测量任务的固定头部小鼠中记录神经活动.
- 利用分类器模型从神经活动中预测试验结果.
主要成果:
- 个体外IC神经元表现出反映听觉线索和小鼠行为的活动.
- 神经群活动轨迹因老鼠的行为选择而异.
- 简单的分类器可以预测试验结果使用神经活动之前的仪器行动.
结论:
- 在行为动物中,听觉中脑神经元编码了声音和动作的联合表示.
- 这表明,集成计算发生在前脑的上游大脑区域.
- 这些发现突出了听觉中脑在处理行为相关感官信息中的作用.
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