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Updated: Jul 15, 2025

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

大规模的单细胞染色体可访问性测序使用组合流体索引.

Xuan Zhang¹, Alexandre P Marand^1,2, Haidong Yan¹

¹Department of Genetics, University of Georgia, Athens, GA, USA.

bioRxiv : the preprint server for biology

|October 3, 2023

概括

此摘要是机器生成的。

单细胞组合流体索引ATAC测序 (scifi-ATAC-seq) 显著增加了分析监管元素的吞吐量. 这种新的方法可以以更低的成本进行高分辨率的基因组研究.

科学领域:

基因组学就是基因组学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
一个单细胞分析.

关键词:

ATAC-seqq 的使用情况.染色体的可访问性染色体的可访问性组合流体索引法组合流体索引法大规模的大规模.单细胞机是一种单细胞机.

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Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease

Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease

Published on: February 1, 2022

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

Published on: November 13, 2017

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Last Updated: Jul 15, 2025

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease

Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease

Published on: February 1, 2022

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

Published on: November 13, 2017

背景情况:

单细胞ATAC-seq对于识别细胞类型分辨率的全基因组调节元素至关重要.
现有的单细胞ATAC-seq方法在吞吐量和成本方面存在局限性.

结论:

scifi-ATAC-seq克服了当前单细胞ATAC-seq方法的吞吐量限制.
能够更全面,更具成本效益地分析 cis 监管要素.
推进单细胞表观基因组学和调控基因组学领域.