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Updated: Jul 25, 2026

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Giorgi Margvelani, Justin R Welden, Andrea Arizaca Maquera

    bioRxiv : the preprint server for biology
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    PubMed
    概括

    前性痴呆的突变会影响循环RNA的形成和翻译. 通过ADAR1-p150编辑RNA影响circTauRNA的表达和蛋白质结合,揭示了新的治疗点.

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    RNA Structure01:23

    RNA Structure

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    The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
    Different Types of RNA Have the Same Basic Structure
    There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
    RNA Stability01:53

    RNA Stability

    Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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    RNA Structure

    Overview
    The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
    Different Types of RNA Have the Same Basic Structure
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    RNA Stability

    Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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    Transfer RNA Synthesis

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