肠道微生物群:在外科手术期间神经认知障碍的发病过程中的新参与者?
Liang Dong1, Juan Li1, Chao Zhang1
1Department of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.
Ibrain
|October 3, 2023
概括
老年患者的外科神经认知障碍 (PND) 与肠道微生物组的变化有关. 准肠道微生物群可能为预防手术后认知衰退提供未来的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 老年病的医生 老年病的医生
背景情况:
- 术后神经认知障碍 (PND),包括术后妄和认知功能障碍,经常影响老年患者,增加发病率和死亡率.
- 驱动PND的确切机制尚不清楚,需要确定可修改的风险因素以改善患者的治疗结果.
- 人们越来越认识到微生物群-肠-大脑轴对中枢神经系统功能的影响,包括行为和认知.
研究的目的:
- 审查有关肠道微生物群在PND发展中的作用的现有文献.
- 探索将肠道微生物组变化与PND病变发生联系起来的机制.
- 评估肠道微生物群作为PND治疗点的潜力.
主要方法:
- 关于临床前和人类研究的综合文献综述.
- 对调查微生物群-肠-大脑轴与认知功能相关的研究进行分析.
- 综合有关术后认知功能障碍患者肠道微生物群疾病的证据.
主要成果:
- 研究表明,在手术和麻醉后,肠道微生物群疾病和认知功能障碍之间存在相关性.
- 临床前研究支持手术和麻醉通过肠道微生物群对中枢神经系统的影响.
- 有证据表明,微生物群-肠-大脑轴在PND中起着重要作用.
结论:
- 肠道微生物群的改变与外科手术期间神经认知障碍的发病有关.
- 肠道微生物组代表了减轻PND的潜在治疗目标.
- 对微生物群-肠-大脑轴的进一步研究可能会导致新的PND预防策略.
相关概念视频
01:05Physiology of Enteric Nervous System and Gut Health
294
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
294
01:21Inflammatory Bowel Disease V: Surgical Management
164
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
164