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在经过后神经疼痛的患者中发生的大脑结构变化:一项VBM-MRI研究

Li Niu^1,2,3, Yi Hu¹, Cheng-Dong Yuan^1,2,3

¹Department of Anesthesiology The Second Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.

|October 3, 2023

概括

脑后神经疼痛 (PHN) 患者在与疼痛处理相关的大脑区域的灰质体积和密度降低. 这些结构变化与疼痛严重程度相关,这表明慢性疼痛与PHN的大脑变化之间存在联系.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
神经学神经学

背景情况:

后神经疼痛 (PHN) 是一种慢性神经病痛疾病.
了解PHN的神经生物学基础对于有效管理至关重要.

研究的目的:

调查PHN患者灰质 (GM) 体积和密度的变化.
探索这些结构变化与临床疼痛措施之间的关系.

主要方法:

基于voxel的形态测量 (VBM) 用于比较25名PHN患者和25名健康对照者的GM体积和度.
在受影响大脑区域的转基因指标和视觉模拟尺度 (VAS) 分数/损伤持续时间之间进行了相关性分析.

主要成果:

与对照组相比,PHN患者的全球GM体积显著降低,脑脊液体积更高.
在包括条纹体,小脑和各种皮层回旋在内的区域观察到减少的转基因体积.
在纹状体,岛状体,环状皮质和上回形中观察到转基因度的下降.
在PHN患者中,右副海马环转基因度和VAS得分之间发现了负相关性.

结论:

PHN与大脑区域的GM体积和密度显著减少有关,这些区域对疼痛感觉,感知和整合至关重要.
这些结构性大脑变化可能在PHN的发展和持续中发挥作用.
这些发现突显了慢性疼痛与PHN中大脑结构变化之间的复杂相互作用.

关键词:

脑子脑子脑子大脑灰色物质是一种灰色物质.磁共振成像技术的使用术后性神经疼痛术后性神经痛基于voxel的形态测量方法

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