通过通用心室辅助装置保持脉动性:对双心室支持的体外评估
Taiyo Kuroda1, Chihiro Miyagi1, Anthony R Polakowski1
1Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Artificial organs
|October 3, 2023
概括
全面心室辅助装置 (UVAD) 在用作双心室辅助装置 (BVAD) 时有效地保持脉动性. 这项体外研究表明,它能够在各种心力衰竭条件下优化心脏输出.
科学领域:
- 心血管工程 心血管工程
- 生物医疗设备 生物医疗设备
- 血液动力学 血液动力学
背景情况:
- 在配置为双心室辅助装置 (BVAD) 时,评估通用心室辅助装置 (UVAD) 的脉动性保护.
- 在实验评估中使用一个体外脉动的双心室循环循环模拟循环.
研究的目的:
- 评估UVAD在作为BVAD工作时的脉动性保护能力.
- 评估UVAD支持在模拟心力衰竭条件下对血液动力学参数的影响.
主要方法:
- 在循环模型中,在双重设置 (BVAD) 中测试两个UVAD.
- 模拟左心力衰竭,右心力衰竭和双心室心力衰竭 (BHF) 的情况.
- 测量总流量,大动脉脉压,脉冲增强因子 (PAF),能量等价压力 (EEP) 和多余的血液动力能量 (SHE) 在不同的速度.
主要成果:
- 与基线相比,在所有模拟的血液动力学条件中,大动脉脉压增加.
- 脉冲增强因子 (PAF) 在健康和轻度的HF条件下从17%到35%不等,在严重的BHF中达到90%.
- 能量等价压力 (EEP) 与LVAD流量 (R2 = 0.87-0.97) 有着强烈的相关性,并比基线增加.
- 过剩的血液动力能量 (SHE) 在5-6 L/min LVAD支持处达到顶峰,在更高的流量下降,在轻度BHF中观察到的最大下降 (53%).
结论:
- 在实验室中,UVAD证明了保持脉动性的能力.
- 在UVAD优化心脏输出既作为一个孤立的设备 (RVAD或LVAD) 和在BVAD配置.
- 紫外线对抗剂显示出作为一种多功能循环支持选项的前景.
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