血清生物标志物与早期认知,粉样蛋白和灰质变化的纵向关联
Steffi De Meyer1,2,3, Elena R Blujdea4, Jolien Schaeverbeke2,3
1Laboratory for Molecular Neurobiomarker Research, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium.
Brain : a journal of neurology
|October 3, 2023
概括
血清质纤维酸蛋白 (GFAP) 和神经丝光 (NfL) 预测了老年人的认知能力下降. 这些生物标志物,以及Aβ1-42/Aβ1-40,为阿尔茨海默病的进展提供了预后见解.
科学领域:
- 生物标志物 生物标志物
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 基于血液的生物标志物对于阿尔茨海默病 (AD) 诊断至关重要.
- 血清生物标志物对认知衰退,粉样β (Aβ) 积累和灰质损失的预后和监测能力需要在没有损害的老年人中进行扩大调查.
研究的目的:
- 在长时间内检查血清质纤维酸蛋白 (GFAP),神经丝光 (NfL),Aβ1-42/Aβ1-40,酸化 (pTau) 181在认知不受损的老年人中的预后和监测潜力.
- 评估这些生物标志物与认知衰退,Aβ积累和灰质损失的关联.
主要方法:
- 对185名没有认知障碍的老年人进行前性队列研究 (平均年龄69岁).
- 基线和纵向评估包括血清生物标志物量化 (GFAP,NfL,Aβ1-42/Aβ1-40,pTau181),Aβ-PET,MRI和多达11年的认知测试.
- 采用了线性混合效果模型和声音分析.
主要成果:
- 高血清GFAP和NfL预测了未来的记忆和语言衰退.
- 低血清Aβ1-42/Aβ1-40预测记忆力下降和Aβ积累.
- GFAP和NfL增加与灰质损失相关,而NfL增加与认知能力下降相关.
- 血清GFAP,NfL和pTau181随着时间的推移而增加;Aβ1-42/Aβ1-40在Aβ-PET阴性个体下降.
结论:
- 血清GFAP,NfL和Aβ1-42/Aβ1-40是无症状阿尔茨海默病阶段有价值的预后和监测工具.
- 这些生物标志物为跟踪疾病进展提供了补充,时间和病理依赖的信息.
- 血清Aβ1-42/Aβ1-40在检测Aβ-PET阳性方面表现优于血,而血pTau181在特定测定中表现高.
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