在接受氧化治疗的患者中,光学连贯性断层扫描血管学参数
Jelena B Vasilijević1, Igor M Kovačević1, Risimić Dijana1
1Clinic for Eye Diseases, University Clinical Centre of Serbia, Belgrade; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Indian journal of ophthalmology
|October 3, 2023
概括
在自身免疫患者中长期使用氧化 (HCQ) 显著降低了视网膜血管密度,并扩大了状血管区域 (FAZ). 光学连贯断层扫描血管造影 (OCTA) 可以帮助监测这些高风险患者的视网膜损伤.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 氧化 (HCQ) 通常用于自身免疫性疾病.
- 使用HCQ可能导致视网膜毒性,需要监测.
- 光学连贯断层扫描血管造影 (OCTA) 是用于视网膜血管的先进成像技术.
研究的目的:
- 使用OCTA测量视网膜血管密度和叶无血管区 (FAZ) 面积.
- 评估氧化 (HCQ) 持续时间对自身免疫患者视网膜血管结构的影响.
- 为了比较与HCQ相关的视网膜毒性低风险和高风险患者之间的OCTA发现.
主要方法:
- 一项涉及98名患有自身免疫性疾病的患者的横截面研究.
- 患者被分为三个组:计划的HCQ启动,低风险 (≤5年HCQ使用) 和高风险 (>5年HCQ使用).
- 进行了全面的眼科检查,包括视野测试,光学连贯性断层扫描 (OCT) 和OCTA.
主要成果:
- 与对照组相比,高风险组的表面准带血管密度显著下降 (P=0.030).
- 与低风险和对照组相比,高风险患者的视网膜深层和周围区域的血管密度降低 (P<0.010).
- 在高风险组与对照组 (P<0.018) 显著扩大状血管区域 (FAZ).
结论:
- 患者使用HCQ超过5年表现出显著损失的副和周围血管密度.
- 与低风险患者和对照患者相比,长期使用HCQ的FAZ区域显著增加.
- OCTA是监测高风险患者和分层他们对HCQ诱导的视网膜损伤风险的一个有价值的工具.
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