雾化高盐水对严重COVID-19肺炎患者的炎症媒介的影响:双盲随机对照试验
Mohammad-Taghi Beigmohammadi1, Laya Amoozadeh1, Nikoosadat Naghibi1
1Department of Intensive Care Unit, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Science progress
|October 3, 2023
概括
在严重的COVID-19肺炎患者中,雾化高血压盐水 (HS) 降低了炎症标志物. 然而,这种治疗没有显著影响死亡率,输管或住院时间.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 严重的COVID-19肺炎的特征是过度的免疫反应.
- 高血压盐水 (HS) 是呼吸系统疾病的潜在抗炎剂.
研究的目的:
- 调查雾化HS对严重COVID-19肺炎患者临床症状和炎症状况的影响.
主要方法:
- 60名患有严重COVID-19肺炎的ICU患者被随机分为实验组 (雾化5%盐水) 和对照组 (雾化蒸水).
- 干预措施每天进行4次,持续5天.
- 评估的炎症标志物 (TNF-α,IL-6),临床因素,死亡率,输管率以及ICU/住院时间.
主要成果:
- 雾化HS显著降低了瘤亡因子-α (TNF-α) 和中白素-6 (IL-6) 的水平.
- 观察到白细胞计数,PO2和血清水平的统计学意义上的差异.
- 在住院时间或死亡率方面没有发现显著差异.
结论:
- HS的雾化有效地减少了严重的COVID-19肺炎的炎症.
- 治疗HS似乎没有影响输管率,死亡率或住院时间.
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