血液循环水平较高,但尿液不高 S100A8/A9 识别了不良的COVID-19结果
Leah Mellett1,2, Gaya Amarasinghe2, Christopher W Farnsworth2
1Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri 63108, United States.
ACS infectious diseases
|October 3, 2023
概括
蛋白蛋白 (S100A8 / A9) 与严重的COVID-19有关. 这项研究发现ICU和致命的COVID-19病例中血清calprotectin水平升高,支持其作为预后生物标志物的使用.
科学领域:
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
- 在COVID-19研究研究中.
背景情况:
- 卡尔蛋白蛋白 (S100A8 / A9),一个警报剂,与严重的COVID-19特征的细胞因子风暴有关.
- 之前对S100A8/A9作为COVID-19严重性生物标志物的研究仅限于非美国人群,主要是血清分析.
研究的目的:
- 调查来自美国医院队列的血清和尿液样本中的S100A8/A9水平.
- 评估S100A8/A9作为COVID-19严重程度的预后生物标志物的潜力.
主要方法:
- 在血清和尿液样本中定量S100A8/A9.
- 与COVID-19严重程度相关的S100A8/A9水平的分析,包括ICU入院和死亡率.
主要成果:
- 血清S100A8/A9水平升高与ICU入院 (p = 0.0370) 和致命的COVID-19病例 (p = 0.0018) 有显著关联.
- 在匹配的血清和尿液样本中,S100A8/A9水平之间没有发现相关性.
结论:
- 血清S100A8/A9水平与美国队列中的COVID-19严重程度有关.
- 尿液S100A8/A9不是可靠的COVID-19严重程度的生物标志物,因此不需要进一步调查.
关键词:
在 COVID-19 疫情中,S100A8 / A9 / A9 / S100A8 / A9 / S100A8 / A9 / S100A8 / A9 / S100A9 / S100A8 / S100A9 / S100A8 / S100A9 / S100A9 / S100A9 / S100A8 / S100A9 / S100A9 / S100A9 / S100A8 / S100A9 / S100A9 / S100A8 / S100A9 / S100A9 / S100A8 / S100A9 / S100A9 / S100A8 / S100A9 / S100A9 / S100A8 / S100A9 / S100A8 / S100A9 / S100A8 / S100A9 / S100A9 / S100A8 / S100A9 / S100A8 / S100A9 / S100A8 / S100A8 / S100A9 / S100A8 / S100A9生物标志物生物标志物这是一种calprotectin.预后 预后 预后
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
110
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
110
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
185
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
185