利用介电屏障放电等离子过程,创建再生生物杀伤性ePTFE膜
Irish Valerie Maggay1, Ting-Yu Liao1, Antoine Venault1
1R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chungli 32023, Taiwan, R.O.C.
ACS applied materials & interfaces
|October 3, 2023
概括
介电屏障放电等离子处理创造了抗菌扩展聚四乙烯 (ePTFE) 表面. 阴离子TMAEMA植入的ePTFE有效地杀死和释放细菌,有助于抑制病原体.
科学领域:
- 生物材料工程 生物材料工程
- 表面科学是一门学科.
- 血技术是一项技术.
背景情况:
- 材料的表面修改对于开发先进的功能性表面至关重要.
- 介电屏障放电 (DBD) 等离子体为表面功能化提供了一种多功能方法.
- 开发抗菌表面对于预防感染和控制病原体传播至关重要.
研究的目的:
- 使用DBD等离子体,使扩展聚四乙烯 (ePTFE) 膜具有抗菌性能的功能化.
- 研究修改后的ePTFE表面的抗菌功效和细菌释放能力.
- 探索DBD血处理的ePTFE在病原体制应用中的潜力.
主要方法:
- 使用DBD等离子体与DMAEMA或TMAEMA单体进行EPTFE薄膜的表面修饰.
- 经过修改的ePTFE膜的物理化学表征 (表面能量,表面电荷,多孔性,孔隙大小).
- 评估细菌杀死释放 (K-R) 功能和死结细菌过试验,使用大肠杆菌.
主要成果:
- DBD等离子处理增强了ePTFE的表面能量和电荷,同时保持了高孔径 (>75%) 和大孔径 (>1.0μm).
- 修改DMAEMA和TMAEMA的ePTFE都表现出对大肠杆菌的抗菌活性.
- 与DMAEMA-grafted ePTFE不同的是,TMAEMA-grafted ePTFE在SHMP洗时有效杀死 (99.78%) 和释放死亡细菌.
结论:
- DBD等离子处理是创建抗菌eptfe表面的有效方法.
- 在TMAEMA移植过程中,它会产生阴离子电荷,从而既可以杀死细菌,又可以轻松地去除死细菌.
- 这些发现凸显了DBD等离子处理EPTFE在设计有助于制疾病的表面方面的潜力.
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