在肺移植接受者中,伊萨武科纳的支气管肺透
Antonio F Caballero-Bermejo1,2, Ignacio Darnaude-Ximénez1, Myriam Aguilar-Pérez3
1Clinical Pharmacology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain.
伊萨夫可纳 (ISA) 能够有效地穿透移植受体的肺组织,在上皮层内液中达到适当的度. 这种抗真菌药物在移植后的护理中表现出良好的安全性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 移植医学 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 肺移植接受者容易患入侵性真菌感染.
- 优化抗真菌药物输送到肺部对于有效治疗至关重要.
- 伊萨夫可纳是一种广泛的三醇抗真菌剂.
研究的目的:
- 评估伊萨夫可纳 (ISA) 在肺移植接受者的支气管肺透率.
- 通过时间测定伊萨夫可纳血清和上皮层内膜液度.
- 评估ISA在该患者群体中的安全性和药理动力学概况.
主要方法:
- 一项涉及13名肺移植接受者的药理动力学研究.
- 在服用后2,4小时和24小时测量伊萨夫可纳的血清度.
- 测量Isavuconazole度在上皮层内液在同一时间点.
主要成果:
- 平均血清伊萨夫康纳的度分别在2,4和24小时时为3.30,5.12和6.31微克/毫升.
- 甲状腺内膜液的平均度分别为0.969,2.141和2.812μg/mL,分别在2,4和24小时.
- 伊萨夫可纳呈现出可以容忍的安全性.
结论:
- 伊萨夫可纳在接受肺移植患者的肺组织中达到适当的度.
- 药物动力学特征表明,伊萨夫可纳的有效支气管肺透.
- 伊萨夫可纳是肺移植患者真菌感染的有前途的治疗选择.
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