中枢肥胖症通过对血清度的影响增加结石疾病的风险
Catherine E Lovegrove1, Jelena Bešević2, Akira Wiberg3
1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Journal of the American Society of Nephrology : JASN
|October 3, 2023
概括
中部肥胖症通过提高血清水平增加石风险. 减肥和针对脂肪的疗法可能有助于预防结石.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 结石疾病影响10%的人,并且往往是复发的.
- 肥胖与结石有关,但确切的机制尚不清楚.
研究的目的:
- 调查一般和中心脂肪对结石疾病风险的独立贡献.
- 确定将脂肪与结石形成联系在一起的机制.
主要方法:
- 利用英国生物库数据进行11.6年的观测和遗传流行病学分析.
- 在英国生物银行和FinnGen队列中使用全基因组关联研究和门德尔随机化.
主要成果:
- 一般 (BMI) 和中央 (腰部至部比率,WHR) 脂肪都与增加结石风险独立相关.
- 较高的WHR,而不是BMI,通过提高血清度来增加结石风险,调解12-15%的效果.
结论:
- 内脏脂肪储存通过提高血清来增加石风险.
- 体重管理和向脂肪组织的疗法可以通过影响平衡来帮助预防结石.
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