个性化化疗药物剂量升级在多中心淋巴瘤的狗
Jacob M Siewert1, Daniel L Gustafson1,2, Kristen M Weishaar1
1Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.
Journal of veterinary internal medicine
|October 3, 2023
概括
在患有淋巴瘤的狗中,在15周的CHOP协议中,增加药物剂量往往是成功和安全的. 这种方法实现了100%的客观响应率,显示了对犬癌症治疗的希望.
科学领域:
- 兽医瘤学 兽医瘤学
- 药理学 药理学是指药理学的学科.
- 狗癌症研究 狗癌症研究
背景情况:
- 多中心淋巴瘤是狗中常见的一种癌症.
- 15周的CHOP协议是一种标准的化疗方案.
- 优化药物输送和剂量对于治疗疗效至关重要.
研究的目的:
- 为了确定在15周的CHOP协议内增加药物剂量的可行性,用于多中心淋巴瘤的狗.
- 评估升级剂量的安全性和耐受性.
- 为了确定客观反应率 (ORR),无进展区间 (PFI) 和整体生存时间 (OST).
主要方法:
- 一项前性队列研究,涉及30只新诊断多中心淋巴瘤的狗.
- 狗用15周的CHOP协议进行治疗.
- 如果药物剂量没有引起剂量限制性不良反应 (AEs),则增加药物剂量,并使用VCOG标准评估AEs和反应. 进行了药理动力学分析.
主要成果:
- 在78%符合条件的狗中,药物剂量升级成功 (18/23).
- 温克里斯,环胺和多克索鲁比辛的剂量在很大一部分狗中升级.
- 客观应答率为100%,中位数无进展间隔为171天,中位数总生存时间为254天. 中性贫是最常见的剂量限制性毒性病.
结论:
- 在15周的CHOP协议内,药物剂量升级在患有多中心淋巴瘤的狗中经常可以实现.
- 升级可以安全地进行,并具有可管理的不良事件.
- 该方案表现出高效率,100%的ORR和有希望的生存指标.
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