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接近红外II驱动的花粉微型驱动器用于治疗炎症性肠道疾病

Lijun Cai¹, Xinyue Cao¹, Cheng Zhao¹

¹Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

|October 3, 2023

概括

这项研究引入了近红外II激活的花粉衍生微电机,用于治疗炎症性肠病 (IBD). 这些创新的微型发动机有效地输送药物,在IBD治疗中显示出有前途的结果.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
胃肠病学胃肠病学

背景情况:

炎症性肠病 (IBD) 给健康带来了重大挑战,需要先进的治疗策略.
目前IBD的治疗方法通常涉及全身药物输送,导致潜在的副作用和有限的疗效.
开发有针对性和高效的药物输送系统对于改善IBD管理至关重要.

研究的目的:

开发和评估一种新的近红外II (NIR-II) 激活的花粉衍生微电机 (PDMM) 系统,用于向IBD治疗.
调查PDMM的推进机制和药物载荷能力.
在IBD模型中评估载有德克萨米的PDMM的治疗疗效.

主要方法:

通过将花粉粒涂上金色层来制造PDMM,用于NIR-II光激活.
利用NIR-II辐射产生的不对称热梯度,通过热泳诱导微电机推进.
描述PDMM的粘附性质和药物递送能力.
在IBD模型中评估甲装载PDMMs的体内性能和治疗效果.

主要成果:

在NIR-II辐射下,PDMMs在体内表现出活跃的运动.
花粉粒的独特结构促进了PDMM粘附于胃肠组织.
PDMM有效地输送了德克萨米他,在治疗IBD方面表现出显著的治疗效果.
该系统显示了增强药物输送和胃肠道管理中的治疗结果的潜力.

结论:

激活NIR-II的PDMMs代表了IBD的新和高效的药物输送平台.
PDMM的自我推进和组织粘附能力使其能够在胃肠道中向药物输送.
在治疗炎症性肠病方面,PDMM对临床应用具有显著的前景.

关键词:

在NIR-II中,我们可以看到NIR-II.药物输送是药物输送的过程.通过胃肠道进行管理.微动力机微动力机对于花粉来说,这是一个很好的选择.性结肠炎是一种

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