在肺静脉隔离后,随着时间的推移,左心房基质的动态变化:Progress-AF研究
Lorenzo Marcon1,2,3, Marco Bergonti1,4, Francesco Spera1
1Cardiology Department, University Hospital Antwerp, Wilrijkstraat 10, Edegem, Antwerp 2650, Belgium.
概括
在肺静脉隔离后,心房的患者的左心房基质在动态变化. 基质的回归与心房的负担降低有关,而进展表明心房持续.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 医疗成像医学成像
背景情况:
- 在心房 (AF) 患者中,随着时间的推移,左心房 (LA) 基质的动态变化尚不清楚.
- 肺静脉隔离 (PVI) 是一种常见的AF治疗方法,但其对LA基质的长期影响需要进一步研究.
研究的目的:
- 评估AF患者PVI后LA基质的动态变化.
- 为了比较患有LA电压进展与回归的患者之间的基质特征.
主要方法:
- 一项前性观察性研究,包括接受首次PVI-only或重复切除术的患者.
- 在切除手术之前和之后,对LA进行了高密度映射.
- 由LA段两极电压的显著变化定义的进展/回归.
主要成果:
- 在61%的患者 (进展组) 中,观察到全球和区域LA电压的显著下降.
- 在39%的患者 (回归组) 中,全球和区域LA电压显著增加.
- 基质进展与更频繁的肺静脉隔离和持续的AF复发有关.
结论:
- 在PVI之后,LA基板表现出双向的动态变化 (进展或回归).
- 基质回归与减少的AF负担相关,而进展与持续的AF复发有关,尽管持久的PVI.
- 酸盐基质的动态性质引发了关于基于低电压区域的除策略的有效性的问题.
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