在患有状细胞疾病的儿童中,胃肠道症状,诊断评估和腹部病理
Chinenye R Dike1, Sarah Fittro2, Robert A Oster3
1Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Pediatric blood & cancer
|October 3, 2023
概括
患有状细胞疾病 (SCD) 的儿童经常有腹痛,但胃肠道 (GI) 评估是罕见的. 更多的胃肠道特异性评估可以改善SCD腹痛的诊断和理解.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 儿科血液学 儿科血液学
- 状细胞疾病研究研究
背景情况:
- 患有状细胞疾病 (SCD) 的儿童经常经历急性疼痛,腹部是常见的部位.
- 胃肠道 (GI) 病理可以表现为SCD儿童的腹痛.
- 关于儿科SCD患者在急性疼痛事件期间腹痛的患病率和诊断后果的数据有限.
研究的目的:
- 为了确定患有SCD的儿童患有胃肠道症状的患病率,向急诊室 (ED) 提交或因腹痛住院.
- 评估这些患者的胃肠道特异性评估的频率.
- 在儿科SCD中鉴定与住院治疗腹痛相关的危险因素.
主要方法:
- 在两年时间内,对21岁以下的儿童进行了回顾性研究,他们向ED提出或因疼痛住院治疗.
- 描述性统计数据用于分析临床特征,胃肠道症状以及按年龄和基因型 (状细胞贫血与非状细胞贫血) 的工作情况.
- 后勤回归模型确定了与住院相关的风险.
主要成果:
- 腹部疼痛与分析的23%的遭遇有关 (1279人中有291人).
- 由于腹痛而住院的情况更常见于年龄较大的儿童,患有状细胞贫血,血红蛋白降低和白细胞数量较高的儿童.
- 在患有腹部疼痛的ED患者中,不到50%的患者接受了胃肠道特异性评估.
结论:
- 患有SCD的儿童经常出现腹痛和胃肠道症状,但胃肠道评估往往是有限的.
- 实施胃肠道特异性评估可以提高胃肠道病理的诊断和排除.
- 改善胃肠道工作可以有助于理解腹部作为SCD的主要疼痛部位.
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