相关实验视频
Updated: Jul 15, 2025

09:36
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
29.7K
基于雌激素受体状态的油性鱼类摄入量和乳腺癌之间的关系:孟德尔的随机化研究
Shang Wu1,2, Xindi Ma1,2, Xiangmei Zhang2,3
1Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Breast cancer research and treatment
|October 3, 2023
概括
基因决定的油性鱼的摄入量与乳腺癌的风险降低有关,特别是雌激素受体阴性类型. 对雌激素受体阳性乳腺癌需要进一步的研究.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 癌症研究 癌症研究
背景情况:
- 饮食因素显著影响癌症风险.
- 油性鱼的消费与各种健康益处有关.
- 油性鱼类摄入量与乳腺癌 (BC) 之间的关系需要进一步研究.
研究的目的:
- 使用孟德尔随机化 (MR) 调查基因决定的油性鱼类摄入量与乳腺癌发病率之间的因果关系.
主要方法:
- 利用了英国生物银行 (N=460,443) 的油性鱼类摄入量和乳腺癌协会联盟 (BCAC) 的BC数据的总结数据.
- 采用两样MR,包括逆方差加权 (IVW),MR-Egger和MR-PRESSO进行灵敏度分析.
- 根据身体质量指数 (BMI) 和体重进行多变量MR调整.
主要成果:
- 油性鱼的摄入量与总BC (OR 0.58,IVW),ER+BC (OR 0.44,IVW) 和ER-BC (OR 0.53,IVW) 有负相关性.
- 灵敏度分析表明没有显著的异质性或水平性.
- 多变量MR证实了经过BMI和体重调整后,总BC和ER-BC的负相关性,但不是ER+BC.
结论:
- 油性鱼的摄入量与总乳腺癌的发病率负相关,特别是ER-乳腺癌.
- 有限的证据支持油性鱼类摄入量与ER+乳腺癌发病率之间的联系.
相关概念视频
Odds Ratio
161
The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
161
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K

