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Multifocal Electroretinograms
Published on: December 4, 2011
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加快的氧化毒性视网膜病变 (Accelerated hydroxychloroquine toxic retinopathy) 是一种具有毒性视网膜病变的疾病
Ayushi Mohapatra1, Prasad Gupta1, Dhanashree Ratra2
1Department of Vitreoretinal Diseases, Sankara Nethralaya, 41/18, College Road, Chennai, Tamil Nadu, 600006, India.
Documenta ophthalmologica. Advances in ophthalmology
|October 3, 2023
概括
氧化 (HCQ) 可能导致早期视网膜毒性,甚至在治疗一年内. 定期监测和多焦点电网膜学 (mfERG) 对于早期检测和预防视力损失至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 毒理学 毒理学 毒理学
- 类风湿病学 类风湿病学
背景情况:
- 氧化 (HCQ) 广泛用于自身免疫性疾病.
- 视网膜毒性是HCQ治疗的已知但经常延迟的副作用.
- 在治疗一年内加速发生的毒性不常见,但需要进行调查.
研究的目的:
- 提出一个病例系列的患者经历早期视网膜毒性从HCQ.
- 分析这些病例的临床特征和调查结果.
- 强调早期检测和监测的重要性.
主要方法:
- 在治疗开始后一年内对9名HCQ毒性患者的回顾性评估.
- 系统性并发症的分析,HCQ剂量,治疗持续时间和眼科检查结果.
- 使用多式调研,包括光学连贯断层扫描 (OCT) 和多焦点电网膜扫描 (mfERG).
主要成果:
- 9名患者 (平均年龄54.2岁) 在治疗2至11个月内发展出HCQ毒性.
- 没有发现任何易受影响的系统性疾病.
- 多焦点电网膜学 (mfERG) 在所有患者中显示出诊断变化,而OCT在44.4%中异常.
结论:
- 早期出现的HCQ视网膜毒性,即使没有诱导因素,也可能发生.
- 定期的眼科监测和频繁的随访是必不可少的.
- 多焦点电网膜学 (mfERG) 是用于早期检测HCQ毒性和预防不可逆转的视力损伤的关键诊断工具.
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