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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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相关实验视频

Updated: Jul 15, 2025

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加快的氧化毒性视网膜病变 (Accelerated hydroxychloroquine toxic retinopathy) 是一种具有毒性视网膜病变的疾病.

Ayushi Mohapatra1, Prasad Gupta1, Dhanashree Ratra2

  • 1Department of Vitreoretinal Diseases, Sankara Nethralaya, 41/18, College Road, Chennai, Tamil Nadu, 600006, India.

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|October 3, 2023
PubMed
概括

氧化 (HCQ) 可能导致早期视网膜毒性,甚至在治疗一年内. 定期监测和多焦点电网膜学 (mfERG) 对于早期检测和预防视力损失至关重要.

关键词:
加快的HCQ毒性毒性在 HCQ 视网膜病变.氧化chloroquine 的使用情况.氧化chloroquine的毒性 氧化chloroquine的毒性多焦点ERG是什么意思

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相关实验视频

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科学领域:

  • 眼科医生 眼科 眼科
  • 毒理学 毒理学 毒理学
  • 类风湿病学 类风湿病学

背景情况:

  • 氧化 (HCQ) 广泛用于自身免疫性疾病.
  • 视网膜毒性是HCQ治疗的已知但经常延迟的副作用.
  • 在治疗一年内加速发生的毒性不常见,但需要进行调查.

研究的目的:

  • 提出一个病例系列的患者经历早期视网膜毒性从HCQ.
  • 分析这些病例的临床特征和调查结果.
  • 强调早期检测和监测的重要性.

主要方法:

  • 在治疗开始后一年内对9名HCQ毒性患者的回顾性评估.
  • 系统性并发症的分析,HCQ剂量,治疗持续时间和眼科检查结果.
  • 使用多式调研,包括光学连贯断层扫描 (OCT) 和多焦点电网膜扫描 (mfERG).

主要成果:

  • 9名患者 (平均年龄54.2岁) 在治疗2至11个月内发展出HCQ毒性.
  • 没有发现任何易受影响的系统性疾病.
  • 多焦点电网膜学 (mfERG) 在所有患者中显示出诊断变化,而OCT在44.4%中异常.

结论:

  • 早期出现的HCQ视网膜毒性,即使没有诱导因素,也可能发生.
  • 定期的眼科监测和频繁的随访是必不可少的.
  • 多焦点电网膜学 (mfERG) 是用于早期检测HCQ毒性和预防不可逆转的视力损伤的关键诊断工具.