异体质银 (I) 和金 (I) N-异环碳复合物:结构特征,计算分析,氨酶抑制和生物效应
Abdollah Neshat1, Atiyeh Mahdavi2, Mohammad Reza Yousefshahi1
1Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), 444 Prof. Sobouti Blvd., Gava Zang, Zanjan 45137-66731, Iran.
Inorganic chemistry
|October 3, 2023
概括
新的银和黄金复合物与硫联体被合成和特征. 这些金属复合物表现出潜在的抗癌和抗菌活性,需要进一步研究治疗应用.
科学领域:
- 协调化学和无机合成.
- 计算化学和电子结构分析.
- 药用无机化学和生物评估.
背景情况:
- 由于其多样化的应用,N-异环碳 (NHC) 金属复合物引起了人们的兴趣.
- 硫供体连接物,如dialkyldithiophosphates和bis(2-mercapto-1-methylimidazolyl) 酸盐,可以调节金属复合物的特性.
- 了解电子结构对于预测和优化生物活动至关重要.
研究的目的:
- 合成和表征新型异体质单核银 (I) 和金 (I) 复合物.
- 研究合成的金属复合物的电子特性和结构特征.
- 评估生物活性,包括抗癌,抗菌,抗铁酶和血液溶解作用.
主要方法:
- 合成 (NHC) M-Cl 复合物 (M = Ag,Au) 与硫供体连接体.
- 单晶X射线衍射用于结构确定.
- 时间依赖密度功能理论 (TD-DFT) 和电子属性的洞电子分析.
- 在体外对MCF-7癌细胞,格拉姆阳性和格拉姆阴性细菌进行生物测试.
主要成果:
- 一系列异质单核银(I) 和金(I) 复合物的合成成功.
- Ag(I) 复合体表现出三角形平面几何,而Au(I) 复合体显示出近线性几何.
- 电子结构分析提供了对复合体电子特征的见解.
- 预先的生物查表明,某些复合物具有潜在的抗癌和抗菌作用.
结论:
- 合成的NHC金属复合物具有独特的结构和电子特性.
- 选择的复合物在体外表现出有前途的抗癌和抗菌活性.
- 需要进一步的研究来探索这些新型金属复合物的治疗潜力.
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