电子烟和传统香烟双重使用对慢性鼻炎诊断和手术的影响:一项多中心研究
Graham Pingree1, Jonathan DeShazo2, Theodore Schuman3
1Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
International forum of allergy & rhinology
|October 3, 2023
概括
电子烟和传统香烟的双重使用者面临的慢性鼻炎或功能性内镜外科手术的风险高于独家使用者. 这种增加的风险可能源于细菌,免疫细胞,遗传学和粘膜功能的变化.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
- 毒理学 毒理学 毒理学
背景情况:
- 电子香烟 (EC) 和传统香烟 (CC) 广泛使用,越来越多的人使用这两种 (双重使用者).
- 与独家使用相比,双重EC/CC使用的长期鼻健康影响仍然不完全理解.
- 慢性鼻炎 (CRS),功能性内镜外科手术 (FESS) 和鼻多重症是重要的上呼吸道疾病.
研究的目的:
- 调查EC/CC双重使用与CRS,FESS和鼻多重症的风险之间的关联.
- 为了比较双重EC/CC用户的鼻健康结果与独家EC或CC用户 (单独用户) 的健康结果.
主要方法:
- 追溯队列研究的设计.
- 对大型医疗保健数据库的分析,以识别EC,CC或两者的用户.
- 统计方法用于比较用户群之间的CRS,FESS和多重症的发病率,并对潜在的混因素进行调整.
主要成果:
- 与单个用户相比,双重EC/CC用户的CRS或FESS风险明显高于单个用户.
- 在双重EC/CC用户和单独用户之间没有观察到鼻多重症风险的显著差异.
- 潜在的促成因素包括鼻腔细菌组成的改变,免疫细胞功能,宿主遗传学和粘膜清除机制.
结论:
- 双重EC/CC使用与CRS和FESS的风险增加有关.
- 这些发现表明,EC和CC的联合使用可能通过各种生物途径对鼻腔健康产生负面影响.
- 需要进一步的研究来阐明这些观察到的关联背后的具体机制.
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