脱水素氨治疗对绝经后妇女认知表现的影响:对随机临床试验数据的系统审查
Farhana Sultana, Susan R Davis, Rakibul M Islam1
1From the Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
概括
脱氨 (DHEA) 补充剂似乎没有改善老年女性的认知表现. 这一系统性审查发现,在绝经后的妇女中,DHEA治疗对认知益处没有一致的证据.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 脱氨 (DHEA) 是一种内源性类固醇激素,对认知功能有潜在的影响.
- DHEA补充剂广泛可用,并以各种健康益处销售,包括对老年人群的认知增强.
- 关于DHEA补充剂改善老年女性认知表现的有效性存在不确定性.
研究的目的:
- 系统地审查和评估外源性脱水氨 (DHEA) 对绝经后妇女认知表现的影响.
- 综合随机临床试验的证据,以确定DHEA补充是否提供认知益处.
主要方法:
- 在多个数据库 (Ovid MEDLINE,EMBASE,PsycINFO,Web of Science,Cochrane Central) 进行了系统的文献搜索,截至2022年11月30日.
- 包括的研究是英语随机临床试验 (RCT),涉及绝经后妇女,使用安慰剂或比较器手臂,至少单盲.
- 使用修订后的Cochrane风险偏差工具评估了偏差风险.
主要成果:
- 四项研究符合纳入标准,所有研究都使用每日50毫克口服DHEA剂量.
- 一项为期4周的交叉研究显示,在24名认知正常女性中,DHEA与安慰剂相比,在视觉空间性能上有统计学上显著的改善.
- 没有其他研究表明DHEA治疗比安慰剂改善认知表现;异质性和偏差高风险被注意到.
结论:
- 本系统性审查不支持使用脱氨 (DHEA) 疗法来改善绝经后妇女的认知表现.
- 一项研究中有限的积极发现没有被复制,总体证据不足以推DHEA用于这种人群的认知增强.
相关概念视频
Menopause
191
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
191
Alzheimer's Disease: Treatment
212
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
212
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
147
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
147
Cognitive Development During Adulthood
142
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
142
Alzheimer's Disease: Overview
513
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
513
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K


