身体外膜氧化支持和重症COVID-19患者的结果:基于人口的队列研究
Tak Kyu Oh1,2, In-Ae Song1,2
1From the Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
概括
需要体外膜氧化 (ECMO) 的COVID-19患者年龄较大或有残疾的可能性较小. 复发疫苗显著降低了重症COVID-19患者的ECMO需求和死亡率.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 新型冠状病毒病2019 (COVID-19) 已造成全球卫生危机,一些患者患有严重的呼吸衰竭,需要先进的生命支持.
- 身体外膜氧化 (ECMO) 是重症COVID-19患者的重要干预措施.
- 了解影响ECMO利用和结果的因素对于资源配置和患者管理至关重要.
研究的目的:
- 确定与在重症COVID-19患者中获得ECMO支持相关的因素.
- 确定与需要ECMO的COVID-19患者死亡率相关的因素.
- 评估疫苗接种情况对ECMO需求和结果的影响.
主要方法:
- 使用韩国国家医疗保险服务和韩国疾病控制和预防局数据的回顾性队列研究.
- 包括2020年10月至2021年12月期间被诊断患有COVID-19并入住重症监护室的成年患者.
- 对ECMO (n=455) 和非ECMO (n=12,648) 组进行比较,以分析相关因素和死亡率.
主要成果:
- ECMO支持与年龄较大 (OR,0.95) 和严重残疾 (OR,0.49) 相反相关.
- 强剂疫苗接种状态 (第二剂:OR,0.61;第三剂:OR,0.40) 显著降低了获得ECMO支持的可能性.
- 接收第二次强剂疫苗接种与ECMO患者的死亡率降低有关 (OR,0.33).
结论:
- 疫苗接种和强化疗法似乎减少了对重症COVID-19患者ECMO的需求.
- 补充疫苗与需要ECMO支持的COVID-19患者的生存率提高有关.
- 这些发现强调了疫苗接种策略在缓解严重的COVID-19结果方面的重要性.
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