人环素毒性:道尽头的光?
Romina B Cejas1, Kateryna Petrykey2, Yadav Sapkota2
1Department of Pharmacology and Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA;
Annual review of pharmacology and toxicology
|October 3, 2023
概括
遗传洞察力可以预测和预防由 antracycline 诱导的心脏毒性 (AIC). 在人类诱导的多能干细胞衍生心肌细胞 (hiPSC-CMs) 中验证基因变异有助于生物标志物开发和为个性化癌症治疗发现心脏保护药物.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 人环素诱导的心脏毒性 (AIC) 是癌症治疗中的一个重大临床挑战.
- 识别影响AIC风险的遗传因素对于个性化医学至关重要.
- 目前对AIC相关基因的理解需要进一步阐明机制和功能.
研究的目的:
- 审查与AIC相关的已知基因及其机械作用.
- 突出使用人类诱导多能干细胞衍生心肌细胞 (hiPSC-CMs) 的基因变异的功能验证的重要性.
- 探索患者特异性hiPSC-CMs的潜力,用于新型目标识别和心脏保护药物发现.
主要方法:
- 对识别AIC相关基因的关联研究的综合文献综述.
- 基因的分类基于它们在AIC中的机械含义.
- 讨论在hiPSC-CMs中功能验证对于遗传生物标志物开发的有用性.
主要成果:
- 已确定的AIC基因及其功能通路的概述.
- 强调hiPSC-CMs在验证遗传变异中的关键作用.
- 对患者特异性hiPSC-CMs在发现新型心脏保护策略方面的潜力.
结论:
- 在hiPSC-CM中对AIC相关变异的功能验证对于临床生物标志物实施至关重要.
- 患者特定的hiPSC-CM为个性化心脏保护药物发现提供了一个强大的平台.
- 这种方法将加速下一代AIC预防策略和个性化疗法的开发.
相关概念视频
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:26Physical Properties of Amines
3.2K
Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
3.2K
01:26Toxic Reactions: Overview
1.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.0K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:26Anticholinesterase Agents: Poisoning and Treatment
908
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
908